( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Vineet Malhotra, Ajit Saxena, Nayan Kumar Mohanty, Rajeev Sood, Rahul Reddy, P. B. Sivaraman, Anup Kumar Kundu, Vijay Kulkarni, T. P. Rajeev, D. Ramesh, Anish Desai and Sunaina Anand*


Mitochondria plays a crucial role in male fertility by contributing to energy synthesis, meiosis, spermatogenesis, sperm maturation, and capacitation. Mitochondrial dysfunctions, in particular mitochondrial DNA (mtDNA) mutation, generation of reactive oxygen species (ROS), and lowered antioxidant capacity are associated with male sub-fertility. Under physiological conditions, sperms produce basal level of ROS necessary for sperm function. However, increased production of ROS causes DNA fragmentation and peroxidative damage to sperm plasma membrane, inducing cell death and causing a decline in fertility. Antioxidants could be employed to control the oxidative damage caused by excessive ROS during spermatogenesis. Mitochondrial medicine was introduced into clinical practice based on pathologies caused by abnormal functioning of mitochondria. Since then, various strategies have been implemented to develop mitochondrial therapeutics, including use of vitamins, co-factors, and antioxidants. The major supplementary antioxidants approved to manage male sub-fertility are L-carnitine, CoQ10, vitamin C, vitamin E, and Lycopene, as well as micronutrients such as folate and zinc. Evidence suggest favourable effects of nutraceutical-based antioxidant supplementation, alone or in combination, on sperm parameters such as sperm concentration, motility, and morphology. In this direction, future studies designed to precisely measure dosage, type, and duration of mitochondria-targeted treatments will encourage widespread use in clinical practices.

Keywords: Mitochondria, antioxidants, spermatogenesis.

[Full Text Article]




    JANUARY issue has been successfully launched on 1 JANUARY 2023.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database