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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Rumana Mahmud*, Purabi Sarkar, Syeda Nabila Islam Juthee, Md. Hasnain Mahbub, Mohammed Fazla Alahi and Md. Zillur Rahman


Background: Oral cancer constitutes the sixth most common cancer worldwide and third most common cancer in South-East Asia. Pathologists have played a major role in identifying different histological and immunohistochemical markers that have a direct bearing on both the behavior and treatment of oral cancer. P63 overexpression has been studied as a prognostic and therapeutic target in oral squamous cell carcinoma. The aim of the present study was to evaluate the immunohistochemical expression of p63 and its association with histopathological grading of oral squamous cell carcinoma. Material and Method: This cross-sectional study was conducted in the Department of Pathology, Chittagong Medical College over a period of 21 months. Specimens from 58 patients were fixed in 10% neutral buffered formalin and embedded in paraffin. Haematoxylin and Eosin stained slides of each case was prepared from each paraffin block for proper evaluation of tumor type and grade. Two slides were prepared from representative tumor blocks of each specimen and stained with primary antibodies against p63 (mouse monoclonal Ab-1; DAKO Denmark). Finally the association between histological grading and p63 expression was assessed by Chi-square test and later intergroup analysis was done between different grades of squamous cell carcinoma by bonferroni test. Result: The mean age of the patients with breast carcinoma studied was 56.98 ± 12.96 years, years ranging from 30 to 80 years; the majority of the cases (62.1%) were of grade I. Among the 58 patients, maximum were grade I with low p63 expression in 23 cases (39.6%) but grade II and grade III were high p63 expression respectively in 17 cases (29.3%) & 3 cases (5.17%).There was statistically significant association between p63 expression and grading of OSCC whereas no significant relationship was detected between markers immunoreactivity and patients age, gender, tumor location and other risk factor. In post hoc analysis, significant association found between grade I and grade II (p=0.0001) and also significant between grade I and grade III (p=0.002). No significant association was observed between grade II and grade III (p=1.00) of OSCC. Conclusion: The immunohistochemical evaluation of p63 overexpression significantly associated with higher grade of OSCC. So it can be used as a prognostic marker and potential targeted therapy of OSCC. Larger sample sizes using standardized tests are needed to understand the exact biological role of p63 in this type of carcinoma.

Keywords: Oral cancer, Oral squamous cell carcinoma, Poor hygiene, Poor diet.

[Full Text Article]




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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database