EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

DESIGN DEVELOPMENT AND FABRICATION OF PHARMACEUTICAL CO-CRYSTAL: ENHANCE AQUEOUS SOLUBILITY AND IN-VITRO DISSOLUTION RATE OF BCS CLASS 2 OR 4 ACTIVE PHARMACEUTICAL INGREDIENT

Priyanka S. Gala*, Mohammad Wais and Indira Parab

ABSTRACT

In last couple of years many API discoveries found to be poorly soluble in aqueous medium. These poorly soluble APIs have low bioavailability & low absorption. So, to deal with this challenge co-crystal technique found to be boon to pharmaceutical industry. Co-crystals optimize the In-vitro powder dissolution rate of Biopharmaceutical classification system (BCS) class 2 or 4 drugs. Crystalline structure of co-crystals comprises of API and one or more Co-former must be either amino acid or carboxylic acid such as (oxalic acid, succinic acid, serine, proline, glycine, etc.) In stoichiometric ratio hydrogen bonded interactions done between drug and Co-former which improves the aqueous solubility of co-crystal. Co-crystals are prepared by following methods such as Liquid assisted grinding, Hot melt extrusion method, Solvent evaporation method, Anti solvent method, Spray drying method, etc. And further characterized by High performance liquid chromatography, Fourier transform infrared spectroscopy, Differential scanning calorimetry, Powder x-ray diffraction and In-vitro dissolution studies of the formulation.

Keywords: Co-crystal, Co-former, Solubility Enhancement, Co-crystal screening, Synthon approach, Theoretical screening.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database