“OVERVIEW: FORMULATION ASPECT OF MUCOADHESIVE MICROSPHERE AND ITS PHARMACEUTICAL APPLICATION”

*Pranali Adsul, Ajay Shinde and Suvarna Sonawane

ABSTRACT

The small size and high drug carrier capacity, microspheres are an important component of novel drug delivery systems. The polymer's bioadhesive feature can be exploited make microsphere mucoadhesive microspheres. Bioadhesion is the state in which two materials, at least one of which is biological in nature, are held together by interfacial forces for an extended period of time. Microspheres have a drug core and an outer layer of polymer as a coating material, with diameters ranging from 1-1000m. Mucoadhesive microspheres have advantages such as efficient absorption, increased bioavailability, and increased drug residence time at the site of administration, as well as producing sustained drug release from dosage forms and specific drug targeting to the absorption site. The recent study is undertaken to for mechanism of mucoadhesion, theories of mucoahesion, method of preparation, method of evaluation, and application of mucoadhesive microsphere in drug administration as well as pharmaceuticals.

Keywords: Mucoadhesive microsphere, Method of preparation, Evaluation.