FORMULATION AND EVALUATION OF IN-SITU GELLING MUCOADHESIVE LIQUID SUPPOSITORY OF NIMESULIDE

Vishal Thakur* and Prof. (Dr.) G.D. Gupta

ABSTRACT

The objective of the present study was to develop and evaluate in situ-gelling mucoadhesive liquid suppositories which are liquid at room temperature but forms a gel at body temperature. Liquid suppository of nimesulide, which is a non-steroidal anti-inflammatory drug (NSAID), was developed for use in rheumatic disease and other musculoskeletal disorders in order to improve patient compliance and systemic absorption. The thermo- sensitive mucoadhesive liquid suppositories were prepared by a cold method using poloxamers P407 and P188 (temperature sensitive gelation property), hydroxyl propyl methyl cellulose (HPMC) and Carbopol 934P. These polymers modulate the gel strength and impart mucoadhesive force to suppository bases. The characterization was carried on the basis of gelation temperature, gel strength, mucoadhesive force, and in-vitro release studies. Results showed from in-vitro release studies, that as the concentration of mucoadhesive polymer increases, release rate of the drug was decreased. So, it is concluded that gelation temperature reduced upon addition of mucoadhesive polymer in the poloxamer solution which leads to increase the gel strength and mucoadhesive force.

Keywords: In situ-gelling, NSAIDs, Mucoadhesive, In-vitro release studies, Rheumatic disease.