A RETROSPECTIVE COHORT STUDY ON THE EFFICACY OF METRONIDAZOLE IN PATIENTS WITH TRICHOMONIASIS AT RIMS GENERAL HOSPITAL, SRIKAKULAM

M. Kanaka Prasada Rao* and V.V.V. Satyanarayana

ABSTRACT

Background: Trichomoniasis is a common sexually transmitted disease (STD) among high risk populations. Trichomoniasis is a sexually transmitted infection (STI) usually associated to vaginitis, urethritis, cervicitis and pelvic inflammatory disease, which can cause infertility. Objective: The aim of this retrospective longitudinal study was to determine the efficacy of Metronidazole 2gm stat. in Trichomoniasis in High-Risk female patients attended to RIMS, Srikakulam, Andhrapradesh. Study Design: A cohort of 300 people who attended the STI Clinic and Gynaecology OP in this province was retrospectively analyzed from September 2011 up to April 2014. Material and Methods: Three hundred women (300 from Obstetrics and Gynecology Outpatient Department and STD OPD) patients attending Government General Hospital, attached to the Rajiv Gandhi Institute of Medical Sciences(RIMS), Srikakulam, Andhra Pradesh, India between September 2011 to April 2014, were enrolled in the present study after taking their due consent, with symptoms of trichomoniasis. Their age, occupation, clinical, obstetrical history, and relevant per speculum findings were recorded on a preplanned proforma. Both vaginal swabs and urine samples were subjected to wet smear examination and culture for detection of parasites. Result: With 2 gm Metronidazole as a single dose, we did not get any treatment failures in our study. Summary: Infections with the sexually transmitted protozoan Trichomonas vaginalis are usually treated with metronidazole, a 5-nitroimidazole drug derived from the antibiotic azomycin. Metronidazole treatment is generally efficient in eliminating T. vaginalis infection and has a low risk of serious side effects. Conclusion: With 2 gm Metronidazole as a single dose, we did not get any treatment failure in our study.Our patients tolerated the dose very well. So, we recommend Metronidazole 2 gm stat. dose for the patients with Trichomoniasis.

Keywords: Metronidazole, Trichomonas vaginalis, High risk groups.