EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ASSOCIATION OF THYROID DISEASE IN SYSTEMIC LUPUS ERYTHEMATOSUS

Umme Shaila*, Sadia Israt Zaman, Dr. Aliza Akter and Md Saqif Shahriar

ABSTRACT

Background: Systemic lupus erythematous (SLE) is a chronic autoimmune disease characterized by multisystem inflammation and presence of circulating auto-antibodies directed against self-antigens leading to inflammatory damage of many target organs including the skin, joints, kidney, blood-forming cells, blood vessels and the central nervous system. Objective: To assess the thyroid function status and to identify thyroid status in SLE patients. Methodology: This hospital based cross-sectional study was conducted at the Department of Medicine and Biochemistry in Sir Salimullah Medical College, Dhaka, during the period of January 2018 to December 2019. Adult patients with SLE were approached for inclusion in this study. Total 100 individual were interviewed focusing their socioeconomic status particularly family size and type, household income, years of formal education, occupation along with demographic profile. Moreover, clinical presentation, duration of disease, and severity were assessed. The Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) was used to measure disease activity of the participants. Data collection were done by interviewing the patients and recorded in a separate case record form. Data analysis was done by the statistical program Statistical Package for Social Science (SPSS) version 25.0 (Chicago, Illinois, USA). Results: Among a total number of 50 SLE cases 82% were in euthyroid state, 8% had subclinical hypothyroidism, 6% had hypothyroidism and 4% patients had euthyroid sick syndrome. Among thyroid antibodies, anti-thyroid peroxidase (Anti-TPO) antibody was positive in 48% of SLE cases and anti-thyroglobulin (Anti-TG) antibody was positive in 32% patients. Thyroid disorder was present in 18% of SLE cases and all of them had positive anti-TPO antibody. Conclusion: It may be concluded from this study that thyroid disorders and presence of thyroid auto-antibodies are common in SLE patients and assessment of thyroid function in SLE patients as a part of biochemical and immunological profiles may help in early detection of associated thyroid disorders.

Keywords: Systemic lupus erythematous, autoimmune, lymphocytes.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database