EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

IN VITRO ANTIDIABETIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC AND AQUEOUS EXTRACTS OF SCHEFFLERA ARBORICOLA

Sravani G., Rajeswari A., Kanaka Raju A. and Sunita K.*

ABSTRACT

The nature has provided abundant plant wealth for all the living creatures, which possess medicinal virtues. Therefore, there is a necessity to explore their uses and to ascertain their therapeutic properties. Objective: The objective of the present study was carried out to evaluate the in vitro antidiabetic and anti-inflammatory activity of methanol and aqueous extracts of leaves and stems of Schefflera arboricola. Materials and methods: Antidiabetic activity was determined by α-amylase inhibition assay, here acarbose used as a positive control and in vitro anti-inflammatory activity by albumin denaturation method, standard drug for anti-inflammatory activity was diclofenac sodium. The absorbance values were measured spectrophotometrically at 405 nm. Results: The results suggests that the dose dependent α-amylase inhibition percentage of methanol leaf from 1.53 - 72.43 μg/mL, aqueous leaf from 0.51 - 50.05 μg/mL, methanol stem from 1.22 - 79.96 μg/mL and aqueous stem from 0.10 - 72.84 μg/mL as compared to acarbose at sequential concentrations. Further results found that methanol leaf, methanol stem, aqueous leaf and aqueous stem extracts at concentration from 20 - 120 μg/mL showed inhibition of albumin denaturation was 11.46% - 71.90%, 6.12% - 84.77%, 5.65% - 55.89% and 0.47% - 76.30% respectably, as compared with standard diclofenac. Conclusion: The findings showed that the maximum α-amylase inhibition activity as well as albumin denaturation activity of Schefflera arboricola was observed in methanol stem, hence the extract can be a potential source of antidiabetic and anti-inflammatory agent.

Keywords: Schefflera arboricola, Antidiabetic activity, Anti-inflammatory activity, Alpha amylase inhibition assay, Albumin denaturation assay, Acarbose, Diclofenac.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database