CASE REPORT: ADVERSE DRUG REACTION CAUSED BY IBUPROFEN
*Afrah Muneer, Ashhar Hassan and Athar Hassan
Ibuprofen is a drug largely available as over the counter and on prescription as well, it is mainly indicated for headache, joint pain, inflammatory disease and fever. It is available in combination with various other drugs and paracetamol. Related side effects with non-steroidal anti- inflammatory drugs and aspirin are gastrointestinal ulcers, rash, Steven Johnson syndrome, hepatic toxicity, acute exacerbation of asthma, respiratory skin rashes and anaphylaxis. Ibuprofen is (2RS)-1[4-(2-methyl propyl) phenyl] propionic acid (BP. 2004). Ibuprofen was the first member of propionic acid derivatives to be introduced in 1969 as a better alternative to Aspirin. It inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase (COX) isoenzymes, inhibitor of cyclo-oxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2). Prostaglandins have an important role in the production of pain, inflammation and fever. It may inhibit chemotaxis, alter lymphocyte activity, decreased proinflammatory cytokine activity, and inhibit neutrophils aggregation; these effects may contribute to anti-inflammatory activity. Ibuprofen is supplied as tablets with a potency of 200 to 800 mg. The usual dose is 400 to 800 mg three times a day.
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