EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF PHYLLANTHUS AMARUS TRANSDERMAL PATCHES FOR ANTI-DIABETIC ACTIVITY

Barish*, Abraham Theodore E., B. Kamaleshwari, Meenu Joshi and M. Mumtaj Begum

ABSTRACT

The leaves of Phyllanthus amarus, have been used in traditional medicine by many Asian, Middle Eastern and Far Eastern Countries to treat headache, coughs, abdominal pain, diarrhea, asthma, rheumatism and other diseases. The whole plant are the most extensively studied, both phytochemically and pharmacologically. The aqueous extracts of the leaves have been shown to possess antioxidant, anti-inflammatory, anticancer, anti-diabetic, analgesic and antimicrobial activities. In this study, Transdermal Patches containing Phyllanthus amarus were prepared by Solvent Casting Technique using two different polymers, Pectin and Sodium alginate in various ratios using Polyethylene Glycol 400, Glycerine as Permeation enhancer and plasticizer. The prepared patches were studied and optimized with respect to physicochemical characters, drug-excipient interaction, in-vitro dissolution, release kinetics studies. The combination of Pectin and Polyethylene Glycol produces smooth flexible films. The In-vitro Dissolution studies revealed that the cumulative amount of drug released was decreased as the polymer content of the film increased. Based on in-vitro drug release studies, P6 [PA-Pectin] was found to be better formulation with reliable physicochemical characteristics as it released a maximum amount of drug release 79.32% at 24 hours and followed zero order kinetics. It is concluded as the optimized formulation for effective drug delivery and produce sustained drug delivery.

Keywords: Transdermal patches, Phyllanthus amarus, Pectin, Sodium alginate, Solvent Casting Technique, Franz Diffusion Cell, Anti-diabetic activity.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia