EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

STAGING LAPAROSCOPY AND NEOADJUVANT CHEMOTHERAPY IN THE TREATMENT OF LOCALLY ADVANCED CANCER STOMACH: A PROSPECTIVE STUDY

Haris Bashir*, Iqbal Saleem Mir, Syed Naveed Ul Alam, Omar Mir, Mohammad Anyees Khanday and Arshad Rashid

ABSTRACT

Aim: To study the value of staging laparoscopy and neoadjuvant chemotherapy (NACT) in the treatment of locally advanced gastric cancer (LAGC). Methods: 32 Patients of radiologically proven locally advanced gastric cancer were enrolled for the study. All were subjected to staging laparoscopy, of whom 6 patients were excluded from the study after detecting occult metastasis. The patients were then subjected to 4 cycles of neoadjuvant chemotherapy and were then restaged radiologically, laparoscopically and pathologically. Results: Staging laparoscopy helped in averting unnecessary laparotomy in around 19% by detecting occult metastasis in them. No primary residual tumor (R0 resection rate) was found in 85%. Pathological complete response was seen in 15.38% of the cases and ypT0 -2 was seen in 61.53%, thereby showing significant downstaging post neoadjuvant chemotherapy (P-value= 0.005). Conclusion: Laparoscopy is an effective tool in staging of locally advanced cancer stomach, and Neoadjuvant chemotherapy proves of great significance in downstaging of the disease.

Keywords: Staging laparoscopy, Neoadjuvant chemotherapy, R0 resection, Pathological complete response.


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  • EJPMR: JANUARY ISSUE PUBLISHED

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database