ROSMARINIC ACID EXERTS PROTECTIVE EFFECT ON OXALIPLATIN INDUCED PERIPHERAL NEUROPATHY: BEHAVIORAL, NEUROPHYSIOLOGICAL AND HISTOPATHOLOGICAL EVIDANCE

K.G. Prasanth, Jithin Mathew* and Mokua William onchoke

ABSTRACT

Neuropathic pain is caused by neuron injury in the peripheral or central nerve system. It can be caused by numerous pathological processes. Neuropathy can categorically be caused by the following stimuli: alcohol, chemotherapy drugs like vincristine, platinum, taxanes etc. Peripheral neuropathy is considered as a serious complication of cancer treatment. The study aims to evaluate the effect of Rosmarinic acid on Oxaliplatin induced peripheral neuropathy. Male Sprague dawley rats are used for the whole In vivo studies. The following Pharmacological screening methods such as behavioral assessment by thermal hyperalgesia, thermal allodynia, rotarod, von- frey test, static mechanic hyperalgesia and Formalin test. Animals are sacrificed at the end of the study and excised the sciatic nerves for histopathological analysis. The present research work revealed that Rosmarinic acid had a protective role on chemotherapy induced peripheral neuropathy.

Keywords: Neuropathy, Chemotherapy, Oxaliplatin, Cancer, Hyperalgesia, Sciatic nerve.