( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



*Aswathi V., Sujith S. Nair and Sreena K.


The main objective of the research work is to formulate the Clopidogrel fast disintegrating tablets. Clopidogrel, an antiplatelet drug used to control heart attack, hypertension by inhibiting platelet activation and aggregation. Fast disintegrating tablets disintegrate or dissolve quickly in the saliva without the need of water. The fast dissolving tablets of Clopidogrel were prepared employing different concentrations of sodium starch glycolate, crospovidone and croscarmellose sodium in different combinations as a Superdisintegrant by direct compression technique. FTIR studies for drug & excipients revealed that there is no incompatibility/ interaction between drug and excipients. The developed formulation were then charecterised for their physical appearance, bulk density, tapped density, carr’s index, hausner’s ratio, angle of repose, weight variation, hardness, friability, drug content, thickness, in vitro disintegration, in vitro dissolution and stability studies. The fast disintegrating tablets prepared using sodium starch glycolate, crospovidone and croscarmellose sodium as superdisintegrant showed better result and hence selected as optimized formulation. The optimized formulation was subjected to stability studies under 3 different conditions. From the stability studies after 90 days, it was found that there was no significant change in appearance drug content, friability, hardness, in vitro disintegration and in vitro dissolution. The in vitro drug release from the tablets showed significantly improved drug dissolution with an increase in concentration of the superdisintegrants. Hence these fast dissolving tablet dosage form could be a potential formulation which could improve the bioavailability reducing the dosing frequency, improved patient compliance.

Keywords: Clopidogrel, fast disintegration tablets, direct compression, superdisintegrants.

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  • New Issue Published

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia