DEVELOPMENT AND EVALUATION OF LOADED MICROSPHER OF MESALAZINE FOR COLON DRUG DELIVERY SYSTEM

Dhiraj Kumar*, Vandana Singh and Dr. Shamim Ahmad

ABSTRACT

The current concern is the fabrication and testing of gum microspheres that occur naturally in terms of performance, decay, readiness, cost-effectiveness and mesalazine. Mesalazine is used in the treatment of inflammatory disease. The microsphere mesalazine solution is prepared by the evaporation process using jantan gum and guar gum. Compliance studies in the range of 200 to 400 cm-1 using FTIR showed no significant changes in mesalazine signaling properties and content in all formulations, indicating mesalazine compatibility with auxiliaries. Adjusted microspheres were analyzed for particle size, surface appearance, % yield, efficiency drug efficiency, in vitro extra drug extraction studies, in-vitro drug kinetics and stabilization studies. Thus the microsphere is a bright yellow color and flows freely. Micrometric research of the prepared structure is available within specified limits and shows good mobility characteristics. Scanning electron microscopy (SEM) studies have demonstrated spherical shapes with diameters ranging from 100μm to 200μm. As the concentration of Shantan gum increases, the release of the drug inside the vitreous decreases. Experimental kinetics studies have shown that the prepared microspheres are kept in zero order and are controlled by the distribution of extra drug extraction from the microspheres and that the microspheres are stable. In conclusion, Microsphere provides an effective and efficient method of producing a controlled release of mesalazine with natural Shantan gum as a dose-regulating agent and to increase the dose frequency reduction.

Keywords: Mesalazine; Xanthan gum; guar gum; microspheres; Solvent evaporation.