EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

DEVELOPMENT AND EVALUATION OF LOADED MICROSPHER OF MESALAZINE FOR COLON DRUG DELIVERY SYSTEM

Dhiraj Kumar*, Vandana Singh and Dr. Shamim Ahmad

ABSTRACT

The current concern is the fabrication and testing of gum microspheres that occur naturally in terms of performance, decay, readiness, cost-effectiveness and mesalazine. Mesalazine is used in the treatment of inflammatory disease. The microsphere mesalazine solution is prepared by the evaporation process using jantan gum and guar gum. Compliance studies in the range of 200 to 400 cm-1 using FTIR showed no significant changes in mesalazine signaling properties and content in all formulations, indicating mesalazine compatibility with auxiliaries. Adjusted microspheres were analyzed for particle size, surface appearance, % yield, efficiency drug efficiency, in vitro extra drug extraction studies, in-vitro drug kinetics and stabilization studies. Thus the microsphere is a bright yellow color and flows freely. Micrometric research of the prepared structure is available within specified limits and shows good mobility characteristics. Scanning electron microscopy (SEM) studies have demonstrated spherical shapes with diameters ranging from 100μm to 200μm. As the concentration of Shantan gum increases, the release of the drug inside the vitreous decreases. Experimental kinetics studies have shown that the prepared microspheres are kept in zero order and are controlled by the distribution of extra drug extraction from the microspheres and that the microspheres are stable. In conclusion, Microsphere provides an effective and efficient method of producing a controlled release of mesalazine with natural Shantan gum as a dose-regulating agent and to increase the dose frequency reduction.

Keywords: Mesalazine; Xanthan gum; guar gum; microspheres; Solvent evaporation.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database