EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A DESCRIPTIVE REVIEW ON PHARMACOKINETICS AND PHARMACODYNAMICS PROFILE OF AN ANTIFUNGAL AGENT: CLOTRIMAZOLE

Renu Tushir*, Ajesh Chauhan, Ruchi Bansal, Arman Dalal and Pankaj Kumar

ABSTRACT

Clotrimazole is marketed as a regularly occurring drug under numerous distinct names and via means of numerous agencies because of its antifungal activity. Clotrimazole, an artificial imidazole derivative, is often used domestically for the remedy of vaginal and pores and skin infections because of yeasts and dermatophytes. It shows maximum activity towards Candida spp., Trichophyton spp., Microsporum spp. and Malazzesia furfur (Pityrosporon orbicular) in vitro. In addition, it also has a few in vitro towards Gram positive bacteria, and at very high concentrations shows activity towards Trichomonas spp. In the remedy of vaginal candidiasis, Clotrimazole vaginal pills have produced treatment costs similar with the ones of traditional nystatin vaginal pills. Clotrimazole has been a success in sufferers of non- responsive patients to different antifungal formulations together with nystatin and amphotericin B. Results in trichomonal vaginitis are not impressive. Skin infections because of Candida or dermatophytes had been successfully deals with topical use of clotrimazole. In comparative trials, clotrimazole cream has been as powerful as Whitfield's ointment and tolnaftate with inside the remedy of dermatophytoses , and as powerful as nystatin in cutaneous candidiasis. Clotrimazole topical formulations are well tolerated; however skin infection has withdrawal of remedy in some cases. Candida septicemia and urinary and pulmonary candidiasis had been cured with oral clotrimazole remedy. Results in different kinds of fungal infections, such as pulmonary aspergillosis, had been disappointing. A restricting issue in oral clotrimazole remedy is the excessive occurrence of gastro- intestinal disturbances and neurological reactions.

Keywords: Clotrimazole, Anti-fungal activity, Dermatophytoses, Vaginal pills, Microspore, Trichomonal vaginitis.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database