EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

GENOME WIDE INTEGRATION ANALYSIS - A NEW APPROACH TO PREDICT SUSCEPTIBLE GENE(S) FOR LUNG CANCER

Muthusamy Chinnasamy and Thirunalasundari Thiyagarajan*

ABSTRACT

Genome wide integration study (GWIS) is the new branch of science that deals with complete genome of the cell type with a specific condition. It is a comprehensive approach to test the hypothesis that, multiple genes work together and account for disease. Diagnosis of the disease at early stage is essential to cure the cancer. Methods available for cancer diagnosis as of now are all lab based and they are time bound and economically ineffective. Hence, a comprehensive analytical method is an urgent need of the hour to diagnose cancer. This study was aimed to find out a new approach for the detection of susceptible gene(s) for cancer using tensor algorithm. Three datasets were downloaded from GEO database. They are i) GSE18454- normal lung cell (NLC), ii) GDS1204 - lung cancer cell (LCC) and iii) GDS1204 -lung cancer cell treated with Mgd (LCCTD). Pre-processing of the data leads to 7,000 valid genes that are similar in all these 3 datasets. Tensor algorithm was implemented to analyze the data. Results revealed that 93% of genes were classified in to different categories, and the rest 7% genes were insignificant. Of the 93% genes classifiable56% of input genes are down regulated after treatment, 4% of genes are up regulated. Mgd treatment restores the genes expression successfully in 4%. 29% of genes were found to be further up-regulated after treatment. As an outcome a tool, will be provided to medical personale and using that they can analyse genomic data and predict lung cancer gene target(s).

Keywords: Lung cancer, Tensor, Genome Wide Analysis (GWA), PHP, MySQL, Mgd.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )