REVIEW ON ANTICANCER AGENTS FROM THE DEEP OF OCEAN

Vrushali M. Pawar, Gauri S. Raut, Pranjal D. Gite and Sukanya P. Paricharak*

ABSTRACT

Cancer remains one of the major threats to human health worldwide with its high mortality rates. Approximately,19.3 million new cancer cases and almost 10.0 million cancer deaths, were estimated each year worldwide. Lung and breast cancer are the most frequently diagnosed cancers worldwide and are the leading causes of cancer-related death in men and women respectively. There are so many therapies for cancer such as radiation therapy, chemotherapy, Surgery, targeted therapy, immunotherapy, hormone therapy, bone marrow transplant etc. plays major role to treat cancer. However, it is not able to avoid repetition of tumor, side effects of therapies as well as drug opposition. There are various cancers which cannot be controlled well with the help of currently available drugs. Along with terrestrial resources the marine environment is recently emerged. Marine-derived drugs belong to wide variety of chemical classes including terpenes, alkaloids, polyketides, peptides, cyclodepsipeptides, shikimates, hydroxyphenylactic Acid derivatives etc. These agents have the potential to inhibit the human tumor cell growth via in-vivo as well as in vitro cancer cell mechanisms. Marine environment represents diverse resource for novel anticancer drugs. There are various properties seen in marine compounds from antibacterial, antidiabetic, antiviral, anti-inflammatory to anticancer. This review provides an overview on the development of marine-derived compounds for cancer therapy along with its possible scope in future. We also discuss about the commercial, potential marine-derived anticancer compounds Along with drugs that are in different phases of clinical trials.

Keywords: Marine-derived compounds, anti-cancer, Molusca, Marine fungi, Marine sponges.