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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

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European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

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Ogbu, I.S.I, Ugwu, M.C, Ukibe, N.R, Mbachu, N.A, Ogbu, C.C, Nwobodo, E.I


Malnutrition leads to immune impairment, worsens HIV infection and can contribute to more rapid progression to AIDS. This study assessed the nutritional status of people living with HIV/AIDS (PLWHA) attending Nnamdi Azikiwe University Teaching Hospital Nnewi in Anambra State, Southeast Nigeria. Fifty (50) PLWHA (twenty five [25] drug naïve and twenty five [25] on treatment) were recruited for the study. Clinical status of the subjects were obtained from the hospital records. A questionnaire and Subjective Global Assessment form were used to obtain nutritional status of the subjects. Serum total protein, albumin and haemoglobin were assayed spectrophotometrically while iron, copper, zinc and selenium were assayed using AAS. CD4+ count of the patients was done by flow cytometer. The results showed that body mass index, BMI (19.20±2.04kg/m2), mid upper arm circumference, (MUAC) 1.88m2 ±0.14 m, CD4+ count (309±140), albumin (2.30±0.27g/dl), Hb (11.92±1.10g/dl), serum iron (0.54±0.0.05ppm), zinc (0.58±0.09ppm) and selenium (0.57±0.06ppm) of drug naïve patients were significantly lower than those of on-treatment group; BMI-22.74±2.59kg/m2, CD4+ count 486± 119, albumin 2.68±0.27g/dl, Hb 12.82±1.12g/dl, serum iron 0.63±0.08ppm, zinc 0.75±0.11ppm, and selenium 0.72±0.09ppm and control group; BMI -22.74±2.59kg/m2, albumin – 3.44±0.36g/dl, Hb – 13.58±0.21g/dl, iron -18±0.14ppm, zinc - 1.18±0.15ppm, selenium - 1.06±0.14ppm, (p = 0.00). The parameters of the on-treatment group; BMI- (22.74±2.59kg/m2), CD4+ count (486±119), albumin (2.68±0.27g/dl), Hb (12.82±1.12g/dl), serum iron (0.63±0.08ppm), zinc (0.75±0.11ppm) and selenium (0.72±0.09ppm) as well as mid upper arm circumference (2.11±0.35m) were also significantly lower than those of the control group (p = 0.00). However, serum total protein (9.63±1.71g/dl), and copper (1.35±0.17ppm) of the drug naïve patients were significantly higher than those of the on-treatment (8.48±1.93g/dl, 0.81±0.12ppm) and control groups (7.05±0.84g/dl, 0.77±0.09ppm), (p = 0.00) while those of the on-treatment group were also higher than the control (p – 0.00).Subjective Global Assessment index showed that 56% and 40% respectively of the drug naïve and on-treatment HIV/AIDS patients were undernourished. PLWHA studied were undernourished and this can hinder effective management. Abnormal trace element levels seems to be basically due to the presence of the HIV in the host and might not be corrected by drug treatment alone. Adequate nutrition deserves even greater attention in the management of PLWHA especially in economically poor setting.

Keywords: “Nutrition”, “nutritional status”, “malnutrition”, “HIV/AIDS”, “trace elements”.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia