EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EVALUATION OF ANALGESIC AND ANTI OXIDANT ACTIVITIES OF SCHIFF BASES

Shan P. Mohammed*, Namsheer B, Dr.Jyoti harindran, Beena Thomas and Mithun K. Sebastian

ABSTRACT

Schiff bases which contain an azomethine group attract much interest in synthetic chemistry. Schiff bases are used as substrates in the preparations of a number of industrial and biologically active compounds via closure, cycloaddition and replacement reactions. Moreover, Schiff bases are also known to have biological activities such as antibacterial, antifungal, antitumor, antioxidant and analgesic activities. INH Schiff bases have better anti-tubercular activity than parent drug isoniazid. In the present study, three different Schiff bases of INH were prepared and the analgesic and anti-oxidant activities were investigated. Analgesic activity was evaluated by acetic-acid induced writhing test in which the Diclofenac was used as the standard drug. In vitro antioxidant activity of the INH Schiff base analogues were evaluated using DPPH free radical scavenging method. In acetic acid induced writhing test, the study showed that there was a significant inhibitory effect on writhing by all the compounds. DPPH radical scavenging activity of the three INH Schiff base analogues at different concentrations (100-500μg/ml) was compared with standard antioxidant ascorbic acid (100-500μg/ml). The compounds showed significant increase in free radical scavenging activity in a dose dependent manner.

Keywords: azomethine, diclofenac ,schiff base,DPPH,acetic acid.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )