EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

UV SPECTROSCOPIC METHOD DEVELOPMENT AND VALIDATION FOR DETERMINATION OF LAMIVUDINE IN BULK DOSAGE FORM

Ravi Kiran*

ABSTRACT

A simple, accurate and cost efficient UV Spectrophotometric method has been developed and validated for various parameters as per ICH Guidelines for estimation of Lamivudine in bulk powder and tablet dosage form. Distilled water was selected as diluents for proposed method for quantification of Lamivudine in bulk and pharmaceutical dosage form. The Lamivudine showed maximum absorbance at 260nm using distilled water as diluent. The sensitivity of the method is good and also the linearity which is observedover wide concentration range of 2-10 μg/ml. Regression equation and correlationcoefficient values were found to be Y = 0.097x + 0.0012 and R2 = 0.999, respectively indicating that proposed method was linear. The accuracy method was determined by recovery studies. The recovery of the drug is well within the acceptance limits of 98-102%. The precision was determined by analyzing the samples of Lamivudine. The% RSD for precision was found to be below 2%. The low% RSD values obtained from the analysis indicated that the method was highly precise.

Keywords: .

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