SYNTHESIS AND ANTIFUNGAL SCREENING OF BENZOTHIAZOLE DERIVATIVES CONTAINING THIAZOLIDINONE MOIETY

Indu Singh*

ABSTRACT

A series of novel benzothiazol-2-amine (1), ethylbenzo[d]thiazol2-ylcarbamate (2), (benzo[d]thiazol2-y)hydrazinecarboxamide (3), N-(benzo[d]thiazol2-yl)2-substitutedbenzylidene hydrazinecarboxamide (4-7), 1-(benzo[d]thiazol-2yl)-3-(2-(substitutedphenyl)-4-oxothiazolidin-3yl)urea (8-11) have been prepared. First compound obtained with reaction of aniline, ammonium thiocynate and bromine. After treated with ethyl chloformate, compound 1 was change compound 2. In the next step compound 2 was introduced in reaction with hydrazine producing compound 3. Then it was treated with different aldehydes and give compounds 4-7. Compounds 4-7 were reacted with thioglycolic acid to yield compounds 8-11. Structure of these compounds cleared from IR, NMR and biological properties were tested against some fungi.

Keywords: Benzothiazole, thiazolidinone, antifungal activity, fluconazole.