EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PREPARATION EVALUATION AND OPTIMIZATION OF FENOFIBRATE SOLID DISPERSION

*Akhisha M. and Sujith S. Nair

ABSTRACT

The term ‘solid dispersion’ refers to a group of solid products consisting of at least 2 different components, generally a hydrophobic drug and hydrophilic carrier. The solid dispersion technique is useful to reduce particle size from crystalline to micro-crystalline level, which ultimately enhances aqueous solubility of poorly water soluble drugs. The purpose of this study was to develop and evaluate solid dispersions of Fenofibrate for the effective treatment of hypercholesterolemia. Fenofibrateis a BCS class II drug having high lipophilicity and low solubility leads to poor absorption from GIT. The formulations were prepared using Box-Behnken design. In the present work an attempt was made to prepare Fenofibrate solid dispersion by using various surfactants. Surfactants not only enhances the solubility but also improve physical stability of solid dispersion. SLS, Tween 80, Span 80 were used to find efficient surfactant combination and highest drug release. The carriers is essential for development of solid dispersion and polyvinylpyrroli done is used as a carrier for formulating solid dispersion. The optimized formulation showed drug release of 99.55±0.142% at 60 min. The rate of drug release follows zero order kinetics with non-fickian case II transport mechanism. From the study it was concluded that the F4 formulation (Span 80-0.75 ml, Tween 80- 1.5 ml and SLS – 150 mg) showed the optimum result as a solid dispersion for the treatment of hypercholesterolemia.

Keywords: Soliddispersion, Fenofibrate, Surfactants, Zero order release.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database