PREPARATION EVALUATION AND OPTIMIZATION OF FENOFIBRATE SOLID DISPERSION
*Akhisha M. and Sujith S. Nair
The term ‘solid dispersion’ refers to a group of solid products consisting of at least 2 different components, generally a hydrophobic drug and hydrophilic carrier. The solid dispersion technique is useful to reduce particle size from crystalline to micro-crystalline level, which ultimately enhances aqueous solubility of poorly water soluble drugs. The purpose of this study was to develop and evaluate solid dispersions of Fenofibrate for the effective treatment of hypercholesterolemia. Fenofibrateis a BCS class II drug having high lipophilicity and low solubility leads to poor absorption from GIT. The formulations were prepared using Box-Behnken design. In the present work an attempt was made to prepare Fenofibrate solid dispersion by using various surfactants. Surfactants not only enhances the solubility but also improve physical stability of solid dispersion. SLS, Tween 80, Span 80 were used to find efficient surfactant combination and highest drug release. The carriers is essential for development of solid dispersion and polyvinylpyrroli done is used as a carrier for formulating solid dispersion. The optimized formulation showed drug release of 99.55±0.142% at 60 min. The rate of drug release follows zero order kinetics with non-fickian case II transport mechanism. From the study it was concluded that the F4 formulation (Span 80-0.75 ml, Tween 80- 1.5 ml and SLS – 150 mg) showed the optimum result as a solid dispersion for the treatment of hypercholesterolemia.
Keywords: Soliddispersion, Fenofibrate, Surfactants, Zero order release.
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