EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF BUCCAL PATCHES FOR DELIVERY OF DICLOFENAC DIETHYLAMINE AS A MODEL DRUG

Debjani Das, Niladri Ghosal and Sudipta Das*

ABSTRACT

Diclofenac diethylamine is a non-steroidal anti-inflammatory drug. Here diclofenac diethylamine used as a model drug. This drug is given here as a buccal patch dosage form. In which the main aim is to increase the bioavailability and better absorption, without any first pass metabolism. This dosage form is very much reliable for those patients, who is unconscious, require fast action, and cannot swallow smoothly. This dosage form directly absorbs through the buccal mucosa and avoid enzyme metabolism also. The patches were evaluated by weight uniformity, moisture gain, moisture loss, physical appearance, thickness uniformity, drug content uniformity and in vitro release study.

Keywords: Diclofenac Diethylamine, Model Drug, Buccal Patch, Gelatin, PEG 400, HPMC, Glutaraldehyde.

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