EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

IN VITRO ACTIVITIES OF LINEZOLID, DAPTOMYCIN, MUPIROCIN AND TIGECYCLINE IN CLINICAL ISOLATES OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS IN SKIN AND SOFT TISSUE INFECTIONS FROM NORTH EAST INDIA

Dr. Chimanjita Phukan,* Dr Nahid Anjum and Dr. Giasuddin Ahmed

ABSTRACT

Introduction: Community-Acquired Methicillin-Resistant Staphylococcus aureus(CA-MRSA) has been recognized as an important pathogen for causing Skin and Soft Tissue Infection(SSTI). Treatments of these pathogens are a therapeutic challenge due multidrug resistance. The purpose of our study was to understand the invitro activity of the newer antimicrobials including Linezolid, daptomycin, mupirocin and tigecycline against S.aureus causing Skin and Soft tissue infections. Methodology: The staphylococcus aureus isolates from SSTIs were isolated and processed according to standard protocols. CDC definition, was used to categorized as community acquired and hospital acquired methicillin-resistant S. aureus. Isolates were subjected to antimicrobial sensitivity testing and tested for the presence of inducible clindamycin resistance. Minimum inhibitory concentration by E test was done for linezolid, daptomycin, mupirocin and tigecycline. Results: Of the 112 S.aureus isolates from SSTIs, 61.6% were methicillin resistant S. aureus (MRSA) and 38.4% were methicillin sensitive S. aureus(MSSA). Community acquired MRSA (40%) were more common among outpatients than the hospital acquired infections (29%). Children and young adults presented with most of the SSTIs. The Inducible clindamycin resistance among the S. aureus isolates were found to be 5.36% and among HA-MRSA and CA-MRSA it was 3.3% and 2.2% respectively. Linezolid resistance was 2.67% and MIC ranged 1.5 - 12μg/ml and none of the S aureus isolates were found to be resistant for daptomycin. 2.67% isolates had MICs for tigecycline greater than 1μg/ml and ranged 0.064μg/ml- ≥4 μg/ml. Mupirocin resistance was detected with a prevalence of 1.78% among the S. aureus isolates, all isolates were HA-MRSA. Conclusion: The high prevalence of CA-MRSA and the emergence of multidrug resistant strains highlights on implementation of proper infection prevention policies and antibiotic stewardship program.

Keywords: Staphylococcus aureus, Skin and Soft tissue infection, Linezolid, daptomycin, mupirocin, tigecycline.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )