EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION & EVALUATION OF PROLIPOSOME OF MORIN BY USING SOLVENT EVAPORATION TECHNIQUE

Sachin Bhusari*, Akshay Lokhande and Pravin Wakte

ABSTRACT

The purpose of this study to develop and evaluate Morin pro- liposomes powder oral drug delivery system. Pro-liposomes are phospholipid-based drug delivery system. Proliposomes prepared using solvent evaporation technique by varying lipid phase (phosphatidylcholine/ cholesterol) and Mannitol composition. It promotes drug absorption, increases the efficacy and therapeutic index of drug and also increases stability via encapsulation, biocompatible, biodegradable and non-toxic. Proliposomes formulation was characterized for entrapment efficiency, drug content, surface morphology, number of vesicles. Followed by In-vitro release studies. Oral pro- liposomes powder showed good properties with angle of repose was less than 30, Car’s index and Hausner’s ratio were also less than 21 and 1.25, respectively. The mean size of the vesicle was in the range 200-300 nm. The assay and entrapment efficiency of pro-liposomes formulation were 57.66±0.1 to 96.79±0.4%, respectively. In vitro release of Morin proliposome powder formulation was 96.15 after 24 hrs. which shows good release from the vesicle of proliposome. In vitro studies carried out provides an insight on the stability and enhances dissolution of from proliposome formulation. The solid state characterization like SEM, FT-IR, DSC studies of Morin Proliposome were carried out.

Keywords: Morin, phosphatidylcholine, Box-Behnken design.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database