FORMULATION & EVALUATION OF PROLIPOSOME OF MORIN BY USING SOLVENT EVAPORATION TECHNIQUE

Sachin Bhusari*, Akshay Lokhande and Pravin Wakte

ABSTRACT

The purpose of this study to develop and evaluate Morin pro- liposomes powder oral drug delivery system. Pro-liposomes are phospholipid-based drug delivery system. Proliposomes prepared using solvent evaporation technique by varying lipid phase (phosphatidylcholine/ cholesterol) and Mannitol composition. It promotes drug absorption, increases the efficacy and therapeutic index of drug and also increases stability via encapsulation, biocompatible, biodegradable and non-toxic. Proliposomes formulation was characterized for entrapment efficiency, drug content, surface morphology, number of vesicles. Followed by In-vitro release studies. Oral pro- liposomes powder showed good properties with angle of repose was less than 30, Car’s index and Hausner’s ratio were also less than 21 and 1.25, respectively. The mean size of the vesicle was in the range 200-300 nm. The assay and entrapment efficiency of pro-liposomes formulation were 57.66±0.1 to 96.79±0.4%, respectively. In vitro release of Morin proliposome powder formulation was 96.15 after 24 hrs. which shows good release from the vesicle of proliposome. In vitro studies carried out provides an insight on the stability and enhances dissolution of from proliposome formulation. The solid state characterization like SEM, FT-IR, DSC studies of Morin Proliposome were carried out.

Keywords: Morin, phosphatidylcholine, Box-Behnken design.