EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

COMPARISON BETWEEN THE CHEMICAL COMPOSITIONS AND THE IN-VITRO ANTIDIABETIC AND ANTI-INFLAMMATORY ACTIVITIES OF SALVIA LIBANOTICA’ AND SALVIA OFFICINALIS’ LEAVES ESSENTIAL OILS

Sirine Chehade, Marwa Kobeissy, Hussein Kanaan and Marianne Haddad*

ABSTRACT

Salvia (Sage) species have drawn a great attention of researchers all around the world due to their countless benefits to support their traditional uses and to find new biological effects. These properties are affected by several environmental factors, which may explain the differences in the magnitude of the reported biological effects between cultivation regions. The purpose of this study was to cultivate S. officinalis in Lebanon and to collect Lebanese endemic S. libanotica to extract their leaves’ essential oil (EO) by hydrodistillation using the Clevenger apparatus, to determine the chemical composition, and to evaluate the antidiabetic and anti-inflammatory activities of their EOs using the α-glucosidase and the albumin denaturation inhibition assays, respectively. S. officinalis (1.75% w/w) had a higher EO yield than S. libanotica (0.86% w/w). Eucalyptol and camphor were the main components detected in the two species EO. S. officinalis exhibited an anti-diabetic effect at lower concentrations (5 and 10%) than S. libanotica, however, both species induced at the highest concentration used (75%) a similar α-glucosidase inhibition. Furthermore, the anti-inflammatory effect of the two species was not statistically different at low concentrations (1, 2.5, and 5%), however, at the concentrations of 10 and 15%, S. libanotica still had a residual anti-inflammatory effect whereas S. officinalis did not. The current study demonstrated early evidence of distinguished anti-diabetic and anti-inflammatory effects induced by the EO of Lebanese S. officinalis and S. libanotica.

Keywords: Salvia officinalis, Salvia libanotica, essential oil, antidiabetic, and anti-inflammatory effects.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia