EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PRE-ANALYTICAL NON-CONFORMITIES OF THE KARYOTYPE

*Patricia Z. Deh, Bi Y.E.B. Goulai, Malika J.A. Dieth, Abou J.L. Okon, Jessica A.L. Koffi, Désirée Q. Coulibaly, B. Doukouré, Victor G. Yao, Isidore M.J.M. Diomandé

ABSTRACT

Purpose: Quality assurance applied to the three phases of karyotype examination namely pre-analytical, analytical and post-analytical allows reliable results to be provider. However, errors or non-conformities (NC) such as insufficient information on the analysis report were noted during the first phase. The objective of this work is to evaluate the pre-analytical non-conformities of the karyotype inherent in the analysis report at the Histology-Embryology- Cytogenetic laboratory of the University Hospital in Cocody-Abidjan. Material and methods: This was a retrospective and descriptive study that was carried out in the Histology-Embryology-Cytogenetic laboratory of the Cocody University Hospital. The non-conformities of the karyotype prescription bulletins from 2014 to 2019 were listed on a data collection sheet. These analysis reports came from various health facilities. Results: 12 types of NC were identified on 59 bulletins. The non-conformities of the bulletin relating to the identification of the patient concerned the absence of sex (18.64%), age (28.81%), profession (100%), place of residence (100%) and the phone number (100%). The last three were the most recurrent. The other non-conformities relating to the prescription that had a low percentage were the absence of the reason for the prescription (1.69%), the identification of the prescriber and the requesting Department (52.24%). In contrast, the absence of the date and time of the sample, the maternal age at conception, recent treatments likely to affect the quality of the examination as well as the family history was the most frequent (100%). Conclusion: The performance of this evaluation made it possible to detect non-conformities related to the reports that could have an effect on the transmission of the result and the quality of the examination. To remedy these errors, the laboratory should carry out preventive and corrective actions such as, the establishment of a model prescription bulletin for the karyotype and the sampling compliance criteria sheet to be offered to the requesting Departments.

Keywords: Karyotype, Pre-analytical phase, Non-conformities (NC), Quality assurance.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database