EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

AN IN-VIVO ASSESSMENT ON THE HEPATOPROTECTIVE ACTIVITY OF ETHANOL EXTRACT OF COCCINIA GRANDIS

Mehnaz Ali*, Sayeeda Sultana, Anonto Gomes, Sabiha Rahman, Arifa Sultana, Jannatul Ferdous, Md. Rafat Tahsin, Jakir Ahmed Chowdhury, Shaila Kabir, Abu Asad Chowdhury, Tahmina Akter, Fahima Aktar, Md. Shah Amran

ABSTRACT

Background: The liver is a crucial detoxifying organ in the mammalian body that also performs a number of metabolic functions. A wide range of toxic substances and drugs have been linked to liver damage. Coccinia grandis have been used to treat a wide range of diseases. In this study, an in vivo assay was conducted to assess the hepatoprotective activity of C. grandis. Method: Fresh C. grandis was collected and dried. Ethanol extract of C. grandis was obtained by mixing 400g of the powder with 2400 ml of 100% ethanol, filtering and then evaporating the filtrate. Test animals were categorized into 14 groups for measuring different parameters to assess the hepatoprotective activity of C. grandis. Result: C. grandis significantly normalized body weight, SGOT, SGPT, ALP, creatinine, total cholesterol, LDL, triglycerides level in CCl4-induced hepatic toxicity containing rodents (p< 0.05). The plant extract also reversed the impaired level of proteins, such as ϒ-GT, SOD, MDA, CAT, LDH which are closely related to hepatic function. Conclusion: This study shows that different doses of C. grandis extracts give significant hepatoprotective activity compared with established marketed drugs. Therefore, more study should be conducted to detect the responsible mechanism to exert desired activity.

Keywords: Hepatotoxicity, SGOT, SGPT, rodent, Coccnia grandis, MDA, CCL4.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • EJPMR: JANUARY ISSUE PUBLISHED

    JANUARY issue has been successfully launched on 1 JANUARY 2023.

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 January 2023 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database