INDICATORS OF ADAPTIVE IMMUNITY IN PREGNANT WOMEN WITH COVID-19

*Musakhodjaeva D. A. and Djumaev K. Ch.

ABSTRACT

Summary: COVID-19 can have negative consequences for pregnant women and their newborns. According to statistics, pregnant women, people over the age of 60 and patients with severe somatic diseases (bronchopulmonary, cardiovascular, autoimmune) were the most sensitive to this virus. The aim of the study: was to study the cellular and humoral parameters of the immune system in women with COVID-19 who were in the third trimester of pregnancy. Material and research methods: We examined 67 pregnant women at 32-37 weeks of gestation who were in Maternity Complex No. 3 in Tashkent with a confirmed diagnosis of COVID-19, which made up 2 groups depending on the severity of COVID-19: 39 women were with moderate and 28 - severe severity. All examined women underwent clinical, laboratory and immunological examination. Immunological examination included determination of the level of cells with the CD3, CD4, CD8, CD16 phenotype in peripheral blood and the level of IgA, IgG, IgM in blood serum by ELISA. Results: It was found that in women with coronavirus infection, depending on the severity, there is an imbalance in the studied parameters of cellular and humoral immunity. Conclusion. In pregnant women with a gestational age of more than 32 weeks, coronavirus infection has a damaging effect on immune system parameters, depending on the severity of the disease. The more severe the disease, the stronger the changes in the state of the immune system are observed.

Keywords: COVID-19, pregnant women, cellular and humoral immunity.