EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

INDICATORS OF ADAPTIVE IMMUNITY IN PREGNANT WOMEN WITH COVID-19

*Musakhodjaeva D. A. and Djumaev K. Ch.

ABSTRACT

Summary: COVID-19 can have negative consequences for pregnant women and their newborns. According to statistics, pregnant women, people over the age of 60 and patients with severe somatic diseases (bronchopulmonary, cardiovascular, autoimmune) were the most sensitive to this virus. The aim of the study: was to study the cellular and humoral parameters of the immune system in women with COVID-19 who were in the third trimester of pregnancy. Material and research methods: We examined 67 pregnant women at 32-37 weeks of gestation who were in Maternity Complex No. 3 in Tashkent with a confirmed diagnosis of COVID-19, which made up 2 groups depending on the severity of COVID-19: 39 women were with moderate and 28 - severe severity. All examined women underwent clinical, laboratory and immunological examination. Immunological examination included determination of the level of cells with the CD3, CD4, CD8, CD16 phenotype in peripheral blood and the level of IgA, IgG, IgM in blood serum by ELISA. Results: It was found that in women with coronavirus infection, depending on the severity, there is an imbalance in the studied parameters of cellular and humoral immunity. Conclusion. In pregnant women with a gestational age of more than 32 weeks, coronavirus infection has a damaging effect on immune system parameters, depending on the severity of the disease. The more severe the disease, the stronger the changes in the state of the immune system are observed.

Keywords: COVID-19, pregnant women, cellular and humoral immunity.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia