A PROSPECTIVE RANDOMIZED CONTROL TRIAL TO STUDY THE EFFECT OF TIMING OF PRE-OPERATIVE ADMINISTRATION OF DEXAMETHASONE AND ONDANSETRON ON POST-OPERATIVE NAUSEA AND VOMITING FOLLOWING LAPAROSCOPIC CHOLECYSTECTOMY

Dr. Manjula Sharma, Dr. Vivek Kumar Garg*, Dr. Surinder Singh and Dr. Shweta Mahajan

ABSTRACT

Background: Post-operative nausea and vomiting (PONV) are potential complications in patients after laparoscopic cholecystectomy. The incidence rate of PONV after laparoscopic cholecystectomy (LC) is higher than that after other types of surgery. Recent interest has been focused on the use of various antiemetics, acting at different receptors at a specific time during surgery. It has been seen that ondansetron is more effective in the initial hours of the postoperative period and dexamethasone is found to be more effective in the late postoperative period after surgery. The present study was aimed to compare the effect of timing of dexamethasone and ondansetron alone when given 45 minutes before induction or given just before induction of anesthesia for control of PONV in laparoscopic cholecystectomy. Methods: This was a randomized prospective study of 200 patients of both sexes in the age group of 20-60 years. Patients were ASA I –II scheduled for elective laparoscopic cholecystectomy. All the patients enrolled for the study were counselled and due informed consent was taken. The data were recorded into an excel sheet and exported to SPSS software (v21.0; IBM, USA). The study was done to compare the effect of timing of dexamethasone and ondansetron alone when given 45 minutes before induction or given just before induction for control of PONV in laparoscopic cholecystectomy, to compare the severity of PONV in all the groups and to compare the amount of rescue anti-emetic consumed in the first 24 hours postoperative period among four groups(A,B,C,D). Categorical variables were presented as frequency and percentages and compared using Chi-Square test. Quantitative variables were expressed as mean and SD, and compared using One-way ANOVA followed by Bonferroni’s post-hoc correction. P-value <0.05 was considered significant.

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