( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Pal Tapas Kumar*, Jayita Mishra and Abhishekh Podder


Pharmacosomes are amphiphilic lipid vesicular systems containing phospholipid complexes with characteristic potential to improve solubility, absorptivity and bioavailability of both poorly water soluble as well as poorly lipophilic drugs. With an objective to improve the aqueous solubility and subsequent bioavailability of a model BCS class III drug, Rosuvastatin Calcium, its Pharmacosomes were developed and subjected to evaluation of physicochemical characteristics. The cumulative release profile and permeation studies had been also done by in-vitro dissolution test, in-vitro diffusion study by modified Franz diffusion cell using egg membrane and in-vivo study for antihyperlipidemic effect by Tritron induced hyperlipidemia animal model. Solubility of prepared Pharmacosomes was found to be higher than pure Rosuvastatin Calcium. Drug content was found to be in the range of 90.4±0.52% to 94.4±0.61% in all the batches of Pharmacosomes. FTIR data also demonstrated superimposed curves to confirm the stability of Pharmacosome complex after 2 months stability study at 40 deg C temp and 75% RH. After 24 hours, maximum drug released from formulation F1 was found as 66.93% in the dissolution study and maximum drug permeated by diffusion through egg membrane from formulation F1 was 49.50% in the diffusion study. In-vitro and in-vivo experiments justify and confirm Rosuvastatin Pharmacosomes formulations as significantly better than Rosuvastatin Calcium as a unique sustained release delivery system with simultaneous reduction of Dosage and improved bioavailability.

Keywords: Pharmacosome, Hand shaking method, Hyperlipidemic, Statins, Log P value, Vesicular systems.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database