HEPATOPROTECTIVE ACTIVITY OF ALLIUM CEPA EXTRACT IN ANTITUBERCULAR DRUGS INDUCED HEPATOTOXICITY IN EXPERIMENTAL ANIMALS

Rajat Sagar, Praveen Kumar, Dr. Shamim Ahmad, Hemant Kumar and Suraj Mandal*

ABSTRACT

The current study is an initiative to examine the hepatoprotective activity of Allium cepa extract in Anti-tubercular drug induced hepatotoxicity in rats. From the Two group of rats one group was given Allium Cepa Extract prior to giving the anti-tubercular drugs for a month time. After the completion of the study the blood of the all animals from both the groups were taken and the liver of all the animals were collected after sacrificing the animal’s using euthanasia. The Liver tissues were processed for histology and the blood samples were subjected to estimate biological parameters and hematological parameters. In in-vivo, Allium cepa extract has no significant decrease in Anti-TB drug induced hepatotoxicity by not reducing the SGPT, SGOT and no significant activity has been observed in other parameters. In histological observations maximum sum score was calculated in disease control group (G2). All the treatment groups showed relatively less damage score when compared to G2 group. Based on the gross and histopathological data, Allium cepa extract treated was found to be well tolerated and there is no safety and toxicity concern.

Keywords: Allium cepa, hepatoprotective activity, Anti-tubercular drug.