IMIDAZOLE DERIVATIVES AND ITS PHARMACOLOGICAL ACTIVITIES

Prachi Ranade* and Anuruddha Chabukswar

ABSTRACT

Imidazole have a distinctive position in heterocyclic chemistry. Imidazole ring have planer nature contains five member ring with 3C and 2N atom in structure. It is a nitrogen based ring which exhibit pharmaceutical as well as biological importance. As imidazole contains two Nitrogen atom both having SP2 Hybridization. The imidazole ring Contains natural bases like Purine, Histidine, and Amino acid. As imidazole is a polarizable ionic aromatic compound it enhance pharmacological properties of lead molecules. It is useful for efficient solubility and bioavailability of some main molecules. The imidazole possess activities like Antibacterial, Antifungal, Antitubercular, and Analgesic. Imidazole nucleus is main strategy for drug discovery. The derivatives containing imidazole have broadened Scope used as remedy for various clinical medicine. Various methods are developed for Synthesis of imidazole and its derivatives having extensive scope in medicinal chemistry. This paper Focuses on chemistry and various pharmacological Actions of imidazole and is derivatives.

Keywords: Analgesic; Anticancer; Antifungal; Antitubercular; Antimicrobial; Imidazole.