A REVIEW ON CAPILLARY ELECTROPHORESIS METHODS FOR IMPURITY PROFILING OF DRUGS

CH. Anupama Swathi* and Tummala Harshitha

ABSTRACT

Capillary electrophoresis is extensively worn for the impurity profiling of pharmaceutical compounds that mainly accommodate stereochemical centers in their structure, analysis of biomolecules and physical properties such as Log P, P ka and depiction of the bio pharmaceuticals, In pharmaceutical analysis capillary electrophoresis have been applied to the determination of adulterants in food stuffs. It determines the purity of pharmaceutical compounds. This article Converse about the general theory and instrumentation of CE along with the classification of various CE techniques, CZE, Capillary MEKC CLEF, CGE. It also Confer an overview of research on the applications of different CE techniques in the impurity profiling of drugs in the past decade. The review briefly Introduce a comparison between CE and liquid chromatography methods and highlights the strengths of CE using drug compounds as examples. This review will help scientists, fellow researchers, and students to understand the Implementation of CE techniques in the impurity profiling of drugs.

Keywords: Capillary electrophoresis, liquid chromatography.