EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

THE EFFECT OF D-RIBOSE-L-CYSTEINE ON INDOMETHACIN INDUCED OXIDATIVE STRESS AND GASTRIC ULCERATION IN ADULT MALE ALBINO WISTAR RATS

Rosemary N. Orjiako*, Edwin Nwobodo, Peter Okonudo, Chukwudi Onyeka Okonkwo, Uzozie Chikere Ofoego, Chukwunenye Chibuike Ubah

ABSTRACT

Gastric ulceration is the most predominant gastrointestinal syndrome ever recognized. The major etiological factors in the pathogenesis of peptic ulcer disease which is H.Pylori as well as increasing use of NSAIDS lead to increased production of ROS by immune and epithelial cells and by activated neutrophils respectively, resulting in oxidative stress. However, studies have shown that Riboceine is a potent anti-oxidant. The aim of the study was to investigate the effect of D-Ribose-L-Cysteine on indomethacin induced Oxidative stress and gastric ulceration in adult male albino wistar rats. 24 adult male albino wistar rats were randomly divided into four groups of six rats (n=6); normal control group (Grp. 1-received normal saline only), ulcer control group (Grp. 2- received normal saline with indomethacin), treatment group 3 (pre-treated with riboceine for three days), treatment group 4 (pre-treated with riboceine for seven days). Riboceine was administered at 2mg/kg to the animals in the treatment groups. Riboceine administration significantly reduced stomach weight (P<0.05). The increased ulcer index due to indomethacin administration was significantly ihibited following Riboceine pre-treatment for three days and seven days (P<0.05). Riboceine administration for three and seven days significantly reduced malondialdehyde level (P<0.05). Riboceine administration for seven days significantly increased catalase activity (P<0.05). Administration of Riboceine for seven days also significantly increased SOD (P<0.05). In conclusion, this study showed that riboceine can be used in the prevention of gastric ulceration due to its gastroprotective and antioxidant potentials.

Keywords: Riboceine, indomethacin, oxidative stress, gastric ulceration, antiulcerogenic, antioxidant.

[Full Text Article] [Download Certificate]