SYNTHESIS AND BIOLOGICAL EVALUATION OF N-HETEROCYCLIC SUBSTITUTED FLUORO-BENZOTHIAZOLE SULPHONAMIDO ANALOGS AS A POTENTIAL THERAPEUTIC AGENTS
Sri Ranga T.* and Neelesh Chaubey
The present investigation is aimed to synthesize fluorobenzothiazole comprising sulphonamido pyrazole analogs starting from fluoro-chloroaniline to get 2-amino-6-fluoro-7-chloro.[1,3] benzothiazole (I), this was treated with bis-s-methyl ethylene cyanoacetamide in the presence of ethanol to get desired molecules. The synthesized targeted molecules are characterized, docked and screened for their invitro antidiabetic properties.
Keywords: Fluorobenzothiazole, Docking, antidiabetic.
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