( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Azikiwe C. C. A., Enye J. C., Ifezulike C. C. and Anowi C. F.


Therapeutic connotes treatment or management of a disease or disorder while pathologic connotes causative and, or processes of a disease or disorder. Central nervous system (CNS) transmitters are biologic molecules, neuronal or extraneuronal that are involved in the transmission or modulation of signals from one neuron to the other or from neuron to an effecter cell or tissue in order to effect an action in the brain. The action could be excitatory or inhibitory. CNS transmitters can broadly be sub-classified into three based on their site of production and actions in the brain. These are Neurotransmitters that are produced in the neuron, stored in the vesicles, destroyed in the neuron and could act as fast or slow transmitters. Examples of which include glutamate, aspartate, gamma amino butyric acid(GABA), dopamine, acetylcholine, serotonin, histamine, adrenaline and noradrenalin. Neuromodulators that may be produced in the neuron, may be destroyed in the neuron and act predominantly as slow transmitters. A single Neuromodulator may speed up the action of a slow Neurotransmitter, modify the action of a fast Neurotransmitter or combine with another modulator to effect a brain action. Examples of which include purines, pyrimindes, prostaglandins, nitric oxide, hydrogen sulphide and some second messengers. Neurotrophic factors that are neither produced nor destroyed in the neurons and are essentially involved in neuronal gene remodeling. Strictly, speaking they are not CNS transmitters but, are essential in transmission. They include substance-P, enkaphalins, endorphins and the host varieties of growth factors cum derived growth factors. Diseases or disorders like seizures/convulsions, Parkinsonism, Alzheimer’s, Depressions, Mania, Anxiety, Hypertensions, schizophrenia, autism, huntington’s disease, tardive dyskinesia, myasthenia gravis, among others are mediated by one CNS transmitter or the other. Theories in CNS like Mono Amine theory of Affective disorders and Dopamine theory of Schizophrenia implies the classical antidepressants and classical antipsychotics obeying these theories respectively in their mechanisms of actions. Benzodiazepines, relieve anxiety via their actions on GABA. Anxiety is also relieved by buspirone, gepirone and ipsapirone via their effects on serotonine (precisely 5HT1A). Alpha 2 methyldopa, Resapine, Clonidine, Prazocine etc bring down high blood pressure via their actions on adrenaline/noradrenaline. Levodopa, Carbidopa, Entacapone, Tolcapone, Selegelline etc bring relieve in Parkinsonism via actions on dopamine. Conclusions: From afore going and several other numerous instances, one can clearly conclude that CNS transmitters play very crucial roles in mediation of neurological diseases and also form the bedrock in the drug management of these disorders. A clear understanding of CNS transmission is thus sine qua nom to a good management of neurological diseases/disorders.

Keywords: Neurological diseases/disorders, CNS transmitters, Alzheimer and food additives, Pathogenesis, Drugs treatment of CNS disorders.

[Full Text Article]



  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 September 2023 Issue has been Published, Kindly check it on


    SEPTEMBER issue has been successfully launched on 1 SEPTEMBER 2023.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.


  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database