EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

INVESTIGATING THE SYNERGISTIC IN-VITRO ANTI-INFLAMMATORY POTENTIALS OF STANDARDIZED FRUIT EXTRACT OF EUGENIA JAMBOLANA AND STANDARDIZED FRUIT EXTRACT PIPER NIGRUM COMBINATIONS

Vikram Singh*

ABSTRACT

After searching PubMed, Google Scholar, Scopus, and other pharmaceutical databases, it was discovered that no combined anti-inflammatory viewpoints of Eugenia jambolana fruit extract and Piper nigrum fruit extract have been published in an in vitro technique (human red blood cells, HRBC). To investigate the synergistic activity, the E. jambolana standardized fruit extract (EJSFE) and P. nigrum standardized fruit extract (PNSFE) were screened together. EJSFE gave 27.23 percent membrane stabilization/protection in HRBCs at a concentration of 250 μg/mL, whereas PNSFE supplied 32.31 percent membrane stabilization/protection in HRBCs. The anti-inflammatory impact was raised to 58.63 percent when the extracts EJSFE and PNSFE were evaluated combined (at a concentration of 250 μg/mL each). When both extracts were administered at the same time, the anti-inflammatory effect increased by 25 percent to 30 percent. Flavonoids, phenols, tannins, and alkaloids are phytoconstituents present in plant material that play a significant role in mediating anti-inflammatory effects by blocking several inflammatory enzymes. The extract's strong phenolic, tannin, and flavonoid content worked together to stabilize the HRBC membrane in a synergistic way. This paper will pave the way for future research into the creation of novel herbal formulations for the treatment of acute and chronic inflammation.

Keywords: Eugenia jambolana, Piper nigrum, Extract, anti-inflammatory, HRBC Method, Phytoconstituents.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )