NASO-PULMONARY DRUG DELIVERY SYSTEM
*K. Malleswari, D. Rama Brahma Reddy, B. Srilekha, K. Swarna Latha and G. Lokanath
Nasal drug delivery has received a great deal of attention as a convenient, reliable and promising method for the systemic administration of drugs. This is due to high vascularity, large surface area, the avoidance of hepatic first pass metabolism, gut wall metabolism and/or destruction in gastrointestinal tract. Since nasal mucosa offer several benefits for target delivery, a wide variety of therapeutic compounds may be administered intranasally for topical, systemic and central nervous system action.The pulmonary drug delivery system offers several merits over other drug delivery systems and therefore, this delivery route has been in prime focus for various applications like local and systemic therapeutics delivery.
Keywords: Naso-Pulmonary drug delivery, mucociliary clearance, nasal, pulmonary, respiratory tract.
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