EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

THE ROLE OF INTRAOPERATIVE FROZEN SECTION DIAGNOSIS OF SENTINEL LYMPH NODE IN EARLY BREAST CANCER

Dr. Most. Fatema Khatun*, Dr. Mirza Kamrul Zahid, Dr. Md. Zahangir Alam and Dr. Rebeka Sulatana

ABSTRACT

Background: Sentinel lymph node biopsy (SLNB) is now the standard of care for axillary staging in patients with clinical lymph node negative breast cancer. Objective: In this study our main goal is to evaluate the role of intraoperative frozen section diagnosis of sentinel lymph node in early breast cancer. Method: This cross-sectional study was performed at Tertiary medical college and hospital from 2019 to 2020 involving 50 cases of invasive ductal carcinoma (IDC), and 50 cases of invasive lobular carcinoma (ILC) who undergone intraoperative frozen section analysis and confirmatory permanent section analyses that was performed on at least one SLN during definitive breast cancer surgery were included as a sample population. Results: During the study most of the patients belong to 32-42 years age group, 62.5%. Mean age was 36±6.28 years. Besides that, 75% patients married in 13-17 years age and got 1st pregnant by 14-18 years old. 90% cases had estrogen receptor followed by 85% cases had Progesterone receptor, 40% had HER2 positive status. Mean tumor size 18.3mm. In invasive lobular carcinoma group, 30% and 40% positive cases were found in frozen section analysis and permanent of SLN whereas Invasive ductal carcinoma group it was 28% and 31%. In addition, during evaluation about finding of a positive sentinel lymph node, no statistically significant difference was noted in any of variables for ILC versus IDC patients. Conclusion: We can conclude that, frozen section analysis of all SLNs during breast cancer surgery in patients should continue to be the standard of care in order to reduce the risk of the need for a later, separate axillary lymph node dissection.

Keywords: Breast cancer, Sentinel lymph node (SLN) biopsy, Invasive ductal carcinoma (IDC), Invasive lobular carcinoma (ILC).


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia