( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Puja Dutta and Biswadev Bishayi*


Staphylococcus aureus, a major opportunistic pathogen, can cause spacious range of infections in animals and humans. Treatment of S.aureus induced sepsis and inflammatory diseases have become the need of the hour. S.aureus stimulated murine peritoneal macrophages releasesa major chemokine, CXCL8 and aggravate CXCR1 expression on the macrophage surface. CXCL8/CXCR1 axis is pivotal for leucocyte recruitment and bacterial clearance from the site of infection. Extrapolating our previous research works, the effect of gradedbacterial inoculum size and peritoneal macrophage cell count on CXCL8, ROS generation, and CXCR1 expression had been evaluated. Secondly, based on the optimum doses obtained, kinetic-dependent S.aureus infection on CXCR1 expression, its subsequent effect on bacterial phagocytic phenomenon had also been studied. The bacterial inoculums size and macrophage quantity had a regulatory effect on CXCR1 expression on the macrophage surface. Increasing bacterial inoculum or macrophage quantity in the culture medium does not elevate CXCR1 expression on macrophage surface beyond a certain point, suggesting a reconcilable interaction between bacterial components and macrophage essential for receptor expression. According to the results obtained, maximum intracellular phagocytosis occurred at 60 minutes post infection. The magnitude of phagocytic activity wasfound roughly proportional to the surface CXCR1 expression on macrophage surface. Hence CXCL8/CXCR1 axis has a significant role in intracellular bacterial phagocytosis and serves as a potential therapeutic target to control S.aureus infection.

Keywords: CXCL8; CXCR1; peritoneal macrophage; phagocytosis; Staphylococcus aureus.

[Full Text Article]



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    SEPTEMBER issue has been successfully launched on 1 SEPTEMBER 2023.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database