BENZIMIDAZOLE DERIVATIVES AND THEIR ANTIMICROBIAL ACTIVITIES: A REVIEW

Pranali Jadhav*, Priti Gaikwad, Pallavi Dhaware and Atul Barawkar

ABSTRACT

Over the past decade, development of small heterocyclic molecules as potential therapeutics has been an area of major interest. A large number of benzimidazole derivatives are of considerable biological and chemical interest. Many substituted benzimidazoles have been reported to display a large panel of biochemical properties, like anti-microbial, anti-diabetic, anticancer activity, numerous anti-oxidant, anti-parasitic, anti-helmintics. Variation of substituents on the benzimidazole nuclei could potentially affect the interaction of the molecules with biological targets. The versatile synthetic applicability and biological activity of these heterocyclic compounds will help the medicinal chemists to plan, organize and implement new approaches towards discovery of novel drugs. The aim of this review is to focus on the research work reported in the recent two decades on the antimicrobial activity of various benzimidazole derivatives.

Keywords: Benzimidazole, antimicrobial, antibacterial, derivatives, synthesis, compounds.