EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database ,

ISSN 2394-3211

Impact Factor: 6.222

ICV - 79.57

Abstract

GREEN CHROMATOGRAPHIC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF PARACETAMOL & LORNOXICAM USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) IN BULK

Shivangi*, Jain Neetesh Kumar and Soni Priyanka

ABSTRACT

A simple Green (eco-friendly), simple, selective, rapid, precise, reverse phase HPLC analytical method is proposed and validated for the simultaneous estimation of Lornoxicam and Paracetamol using environment friendly solvents. The result observed showed that ethanol: phosphate buffer at pH 3.0 adjusted with orthophosphoric acid in 35:65 ratios, at a flow rate of 1.0ml/min was identified as the best chromatographic method for simultaneous estimation of these drugs in line to green analytical separations. The method was developed on Thermostat hypersil C18 column (5 μm, 250mm x 4.60mm) as the stationary phase. The detection wavelength taken was 262.5nm. The method was validated in accordance with the ICH guidelines and validated for linearity, selectivity, LOC, LOQ and robustness. The result showed that the developed method is precise, accurate and can be applied for determination of the same drugs, for routine analysis with affecting the environment.

Keywords: Green chromatography, Lornoxicam, Paracetamol, Simultaneous estimation.

[Full Text Article]

SJIF Impact Factor: 6.222

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NEWS & UPDATION

New Issue Published
Its Our pleasure to inform you that, EJPMR 1 September 2023 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

EJPMR: SEPTEMBER ISSUE PUBLISHED
SEPTEMBER issue has been successfully launched on 1 SEPTEMBER 2023.

EJPMR New Impact Factor
Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from 5.804 to 6.222, due to high quality Publication at International Level