CLINICO-PATHOLOGICAL STUDY OF COLORECTAL CARCINOMA
Dr. Md Masud Sattar* and Dr. Mahboobur Rahman
ABSTRACT
Background: Adenocarcinoma of the rectum is a major cause of mortality & morbidity in north America & Western Europe. Colorectal carcinoma is the fourth most common variety of malignant tumor found in female and second most in male. Overall, it is the second 1nost common carcinoma in western countries with approximately 18000 patients in the UK dying per annum. The rectum is the frequent site involved. The 5-year survival rate is approximately 50%. Screening & removing adenomatous polyps may improve survival rate. Almost all rectal cancers are primary adenocarcinoma, which arises in rectum as an intramural epithelial lesion, usually in an adenomatous polyp or gland. As cancers grow, they invade the muscularis mucosa and lymphatic and vascular structures to involve regional lymph nodes, adjacent structures & distant sites especially the liver. Objective: The purpose of the study was to consider the serum CEA level as a diagnostic tool for advanced colorectal carcinoma. Methodology: This study was a cross sectional study. This study was conducted by Histopathologically prayed all colorectal carcinoma patients were selected from the surgical wards of DMCH who will meet the selection criteria of the study. 50 cases (Ideally the sample size should be 368 but due to time & resource constraints the present study has been done on 50 cases only). Result: For this purpose, patients’ age ranged from 15 years to 75 years & above were allowed in the study in which 41 (82%) cases had been suffering from rectal carcinoma and rest 9 (18%) from Colonic carcinoma. The present study reveals that serum CEA level is raise in 3 (11.11%) of cases with tumor size 2-5 cm and 21 (91.30%) of cases with tumor size >5 cm; serum CEA is normal in other cases. It was observed that S. CEA level was raised in 100% cases of stage 'D', 92.31% cases of stage 'C', and 30.56% cases of stage 'B' lesion. Conclusion: So, it can be concluded that S. CEA level is significantly higher in advanced stages of carcinoma with or without metastasis and lower in early stages. Conclusively it can be said that S. CEA level could play an important role to determine the diagnosis of advanced stages of colorectal carcinoma and prognosis.
Keywords: Colorectal carcinoma, adenocarcinoma, colon & rectum.
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