EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

CLINICO-PATHOLOGICAL STUDY OF COLORECTAL CARCINOMA

Dr. Md Masud Sattar* and Dr. Mahboobur Rahman

ABSTRACT

Background: Adenocarcinoma of the rectum is a major cause of mortality & morbidity in north America & Western Europe. Colorectal carcinoma is the fourth most common variety of malignant tumor found in female and second most in male. Overall, it is the second 1nost common carcinoma in western countries with approximately 18000 patients in the UK dying per annum. The rectum is the frequent site involved. The 5-year survival rate is approximately 50%. Screening & removing adenomatous polyps may improve survival rate. Almost all rectal cancers are primary adenocarcinoma, which arises in rectum as an intramural epithelial lesion, usually in an adenomatous polyp or gland. As cancers grow, they invade the muscularis mucosa and lymphatic and vascular structures to involve regional lymph nodes, adjacent structures & distant sites especially the liver. Objective: The purpose of the study was to consider the serum CEA level as a diagnostic tool for advanced colorectal carcinoma. Methodology: This study was a cross sectional study. This study was conducted by Histopathologically prayed all colorectal carcinoma patients were selected from the surgical wards of DMCH who will meet the selection criteria of the study. 50 cases (Ideally the sample size should be 368 but due to time & resource constraints the present study has been done on 50 cases only). Result: For this purpose, patients’ age ranged from 15 years to 75 years & above were allowed in the study in which 41 (82%) cases had been suffering from rectal carcinoma and rest 9 (18%) from Colonic carcinoma. The present study reveals that serum CEA level is raise in 3 (11.11%) of cases with tumor size 2-5 cm and 21 (91.30%) of cases with tumor size >5 cm; serum CEA is normal in other cases. It was observed that S. CEA level was raised in 100% cases of stage 'D', 92.31% cases of stage 'C', and 30.56% cases of stage 'B' lesion. Conclusion: So, it can be concluded that S. CEA level is significantly higher in advanced stages of carcinoma with or without metastasis and lower in early stages. Conclusively it can be said that S. CEA level could play an important role to determine the diagnosis of advanced stages of colorectal carcinoma and prognosis.

Keywords: Colorectal carcinoma, adenocarcinoma, colon & rectum.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia