EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

STUDIES ON DESIGN AND DEVELOPMENT OF DISSOLVABLE ORAL DRUG DELIVERY SYSTEMS OF A POORLY WATER SOLUBLE NON-STEROIDAL ANTI- INFLAMMATORY DRUG

T. Sukanya*, S. Srivallika, D. Chandra Sekhar Naik, Aminul Islam Khan, Atif Hussain and Mehabub Hassan

ABSTRACT

The main objective of the present research work is to develop fast dissolving tablets by employing 23 factorial designs with Starch xanthate. The physical and micrometric properties were performed to evaluate the synthesized starch xanthate. The fast-dissolving tablet of Diclofenac was prepared by employing starch xanthate as superdisintegrantin different proportions in each case by direct compression method using 23 factorial design. Starch xanthate exhibited good swelling in water. The study between Diclofenac and starch xanthate was shown the absence of interaction by Fourier transform infrared spectra (FTIR) and differential scanning calorimetry (DSC). The evaluation post parameters of fast dissolving tablets the optimized formulation is F2. The dissolution efficiency of Diclofenac was enhanced when starch xanthate was found to be a super disintegrants when combined with sodium starch glycolate, croscarmellose sodium and, hence it could be used in the formulation of fast dissolving tablets to provide immediate release of the contained drug within 10 min.

Keywords: Fast dissolving, Superdisintegrant, Starch xanthate, Dissolution.

[Full Text Article] [Download Certificate]