EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

DEVELOPMENT OF OMEPRAZOLE LOADED NANOSPONGES FOR GASTRIC ULCER

*Krishnananda Kamath K., V. P. Navya Krishna and A. R. Shabaraya

ABSTRACT

Nanosponges are tiny mesh-like nanoporous particular structure in which a large variety of substances can be encapsulated or suspended, and then be incorporated into a dosage form. They have a proven spherical colloidal nature, reported to have a very high solubilization capacity for poorly soluble drugs. Omeprazole is proton pump inhibitor which is extensively degraded in acidic pH conditions. Omeprazole loaded nanosponges for gastric ulcer were prepared by Emulsion solvent diffusion method by using ethylcellulose, PVA and pluronic F-68 and dichloromethane as a solvent. The prepared nanosponges were evaluated for percentage yield, entrapment efficiency, particle size, drug polymer compatibility, scanning electron microscopy, and in-vitro drug release. SEM studies confirmed their porous structure with number of nanochannels. The FTIR spectra showed stable character of omeprazole in mixture of polymers and revealed the absence of drug polymer interactions. The average particle size of omeprazole nanoparticle was found to be 83.4 to 190.69 nm. The negative zeta potential values were attained to ensure a good stability of nanosponges. The drug release from nanosponges was found to extent upto 7h. The optimized nanosponges were formulated into enteric coated tablet and evaluated for weight variation, friability, hardness, and dissolution studies. In-vitro release of drug from enteric coated tablet follows zero order and showed controlled release behavior for a period of 22 h. The data obtained in this study suggests that nanosponges of omeprazole are promising for controlled drug delivery. This can reduce the dosing frequency.

Keywords: Controlled drug delivery, Nanosponges, Omeprazole, dissolution.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 September 2023 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

  • EJPMR: SEPTEMBER ISSUE PUBLISHED

    SEPTEMBER issue has been successfully launched on 1 SEPTEMBER 2023.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database