EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF EMULGELS CONTAINING ETODOLAC

Vandana M. V.* and Dr. Suja C.

ABSTRACT

Emulgel is a novel drug delivery system with dual control release. Etodolac is a hydrophobic, BCS class-II, anti-inflammatory drug used in the treatment of rheumatoid-arthritis with half-life 4-6 hours. The present study is aimed at reducing gastro-intestinal related toxicities associated with oral administration of Etodolac, and also to improve drug release, permeation, selective absorption of drug at site of action and for enhancing stability. In this study, the effect of various gelling agents and penetration enhancers are also aimed to be studied. Two gelling agents used are carbopol and HPMC. Physical evaluation and rheological studies were done to determine the best gelling agent for preparation of emulgel and it was found that carbopol was a better gelling agent. Hence, further studies to find out the effect of penetration enhancer was done using carbopol as gelling agent. Two penetration enhancers used are propylene glycol and oleic acid. Optimization studies have been done by Design Expert software using Box-Behnken design. 17 formulations were prepared. All the formulations were evaluated for physical appearance, viscosity, pH, spreadability, extrudability, drug content and in vitro drug release. All the formulations showed results within acceptable range. The optimized formulation F4 showed drug release 95.4% and spreadability 30g.cm/sec. Kinetic studies, stability and skin-irritation studies were conducted on the optimized formulation. Mechanism of drug release was found to be zero-order and non-fickian super case-II transport. The stability and skin-irritation studies of optimized formulation confirmed that the formulation was stable and safe for use in animals.

Keywords: Emulgels, etodolac, anti-inflammatory, carbopol, HPMC, optimization.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia