ORAL DISPERSIBLE TABLET- DOSE OF CHOICE IN EMERGENCIES

Umesh Gupta*, Dr. Mukesh Bansal, Dr. Dilip Agrawal, Ashok Kumar Sharma and Dr. Rakesh Goyal

ABSTRACT

Oral Dispersible drug delivery are often an alternate and better choice of route in comparison to other oral drug delivery as Oral administered dosage forms bypass hepatic metabolism. A rapid onset of pharmacological effect is usually desired for a few drugs, especially those utilized in the treatment of acute disorders and need onset of action. Oral Dispersible tablets disintegrate rapidly and therefore the bit of saliva present is typically sufficient for achieving disintegration of the dosage form including better dissolution and increased bioavailability with effective therapeutic range. Oral Dispersible tablets were found to possess better characteristics in comparison to standard conventional dosage forms. Oral Dispersiblely administered tablets achieved better bioavailability, rapid onset of action and better dissolution properties increasing the fast disintegration. The addition of Superdisintegrants facilitated rapid disintegration and this approach is often needed to treat acute disorders or emergency conditions with showing onset of action. The Oral Dispersible route of administration is often used for drugs which undergo first pass metabolism or degradation within the GIT process. Drugs administered Oral Dispersiblely tend to possess better bioavailability which is better approach other than conventional tablets.

Keywords: Fast dissolving/disintegrating tablets, orodispersible tablets, GIT, bioavailability, first pass metabolism, superdisintegrants.