AN OVERVIEW –ANALYTICAL METHODS FOR THE ESTIMATION OF FELODIPINE BULK AND IN PHARMACEUTICAL DOSAGE FORM
Sudha T.*, Priyadharshini B., Priyanka V., Nivetha S. and Pavithra V.
Felodipine is a medication used in the treatment of hypertension. It belongs to the dihydropyridine (DHP) class of
calcium channel blockers. It is widely analysed by HPLC method. Felodipine can be analysed not only in neat
solution but also in pharmaceutical products alone and in combination with other products. Felodipine is also used
to prevent future heart diseases, heart attacks, angina and strokes. This review discusses the different analytical
methods for the estimation of Felodipine. In this review the instruments used are HPLC methods, UV
spectrophotometry, HPLC-UV, HPLC-MS, GC-MS, LC-MS, Chiral normal phase liquid chromatography and
Electrospray ionization mass spectrometry, Chiral stationary phase chromatography and gas chromatography/mass
spectrometry and Ultra sound assisted dispersive liquid-liquid micro extraction coupled with high performance
liquid chromatography. A simple and sensitive stability indicating HPLC method was developed and validated for
the quantitative determination of Felodipine in the presence of its degradation products, using atenolol as an
internal standard. Moreover this review will be useful for further research and studies on felodipine.
Keywords: Felodipine, Calcium channel blocker, Hypertension, Spectroscopy.
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