MONOCLONAL ANTIBODIES: A REVIEW

Pradnya Deolekar*, Kavitha Dongerkery, Pramila Yadav and Prathmesh Deolekar

ABSTRACT

Monoclonal antibodies are a relatively new type of "targeted" cancer or biologic therapy. A variety of mechanisms are thought to play important roles in mediating the anti-tumor effects of mAb. These include signaling mediated by cross-linking of surface antigen that leads to cell death, blocking an activation signal that is necessary for continued cell growth, antibody-dependent cellular cytotoxicity (ADCC), complement mediated cytotoxicity (CMC) and the ability of mAb to alter the cytokine milieu or enhance development of an active anti-tumor immune response.[1]

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